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Rare meta-analyses performed (only four), with only up to three studies included in the analyses, also confirmed positive effects (but only in pairwise meta-analyses, not in network meta-analyses) (220223)

demonstrated that miR-21-5p effectively inhibits apoptosis and oxidative stress in primary cardiomyocytes and mouse heart tissue exposed to DOX, offering potential leads for novel treatments in cardiovascular diseases [622]

[PubMed 9756114] 2269

Molecular characterization of TP53 mutations and copy number change in colorectal cancers, 2017
