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Description
Figure 4 5.2.1 Microglia-mediated ferroptosis propagation Microglial iron accumulation serves as a key trigger for ferroptosis, which in turn amplifies neuroinflammation through the release of pro-inflammatory cytokines (Liu S

Additionally, andrographolide has been shown to mitigate iron accumulation and lipid peroxidation by upregulating SLC7A11 and GPX4 levels in HK-2 cells via the Nrf2/FSP1 pathway, thus attenuating ferroptosis and alleviating septic acute kidney injury (115)

doi: 10.1186/s40478-016-0293-8

Mar 24 2004;291(12):1447-1455
