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Finally, as part of the innate immune response to pathogens, the methionine sulfoxide reductase B1 (MSRB1) selenoenzyme has been found, in murine macrophages, to regulate, through a redox mechanism and remodelling of the actin cytoskeleton, macrophage activation and phagocytosis (Reference Lee, Peterfi and Hoffmann80) and to promote anti-inflammatory cytokine production

doi: 10.1089/scd.2010.0466

This multifaceted process is best understood not as a linear sequence of events but as a self-perpetuating immunopathological circuit, where feedback between the immune system and epidermal cells amplifies the inflammatory response (Baliwag et al

Ashleigh Tindle 2