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Moreover, overexpression of GPX3 further exerted anti-autophagy by inhibiting AMPK/m-TOR and up-regulated nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4, mitochondrial GPX4 and cytoplasmic GPX4) to antagonize autophagy-related ferroptosis

This is important because tissue GSH lowering is commonly noted in the context of several diseases as well as in aging

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It also promotes human myotube formation and fiber diameter, offering a model for treating sarcopenia and muscle atrophy
