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Background: Incretins were discovered after it was observed that administration of an oral glucose load leads to a much greater stimulation of insulin release than a comparable glucose load given intravenously (Hansotia & Drucker, 2005)

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Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA

Additional class-related concerns include: Gallbladder disease , including cholelithiasis (gallstones) and cholecystitis, as observed with GLP-1 receptor agonist medicines [27] Dehydration and acute kidney injury (AKI) risk secondary to significant gastrointestinal fluid losses Increased heart rate , a recognised class effect of GLP-1 receptor agonists Pancreatitis a potential risk that warrants prompt medical assessment if severe abdominal pain develops Thyroid C-cell tumours observed in rodent studies with GLP-1 receptor agonists