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In vitro, 78c (CD38 inh, 0.5 M) also significantly alleviated Ang II-induced VSMC senescence, as shown by the 64.58% reduction in the SA--gal-positive area (Fig

It's whether the research question justifies the added complexity

additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81