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Of note, this divided response pattern was unique to ferroptosis, as the same murine and human SCLC cell line panels did not show a bipartite response to cisplatin or etoposide (Supplementary Fig

Using in vitro tag-free mature AIF-based biochemical assays, cellular loss-of-function and gain-of-function studies, and AIF3 splicing models in vivo, we further found that full-length mature AIF was a mammalian mitochondrial complex I alternative NAD(P)H dehydrogenase and possessed previously unrecognized glutathione reductase (GR) activity, whereas AIF3 lost GR and NAD(P)H dehydrogenase activities

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12 Conclusion Organosulfur compounds (OSCs) represent a promising class of dual-action therapeutic candidates, uniquely positioned to address antimicrobial resistance by simultaneously suppressing pathogenic fitness and enhancing host immune competence