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doi: 10.1038/npp.2014.168
The identified mechanisms include: Competitive Reuptake Inhibition: Amphetamine enters the presynaptic neuron either by passive diffusion or by acting as a competitive substrate for the plasma membrane monoamine transporters
Detoxamin works gently with a quarter of the dose usually given by the IV method and does not have the same chelation therapy side effects
But unless the mechanisms are complementary rather than redundant, stacking adds cost and complexity without proportional benefit
