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Metabolism In vitrostudies in human liver microsomes show that trazodone is metabolized, via oxidative cleavage, to an active metabolite, m- chlorophenylpiperazine (mCPP) by CYP3A4
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The crystal structure of this complex revealed important details about how F2PhEtyCbl interacts with CblC and glutathione, providing new insights into the enzyme's mechanism and the potential effects of antivitamins on B12 metabolism
