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Two, people with genuine B12 deficiency are, after withdrawal, at risk of developing worse symptoms, which may even persist after resuming treatment

Cancer Med 4(6):825-33, 2015

Moreover, internal triggers like excess sugar, processed foods, trans fats, and hormonal dysregulation (like insulin resistance or PCOS) can worsen acne and delay wound healing

Dosing in the morning can help buffer this transition and get the blood moving into stiff joints [4, 7]
