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Furthermore, acyl-ghrelin was found to bind to the ghrelin receptor by effectively utilizing this bifurcated pocket. In addition to promoting GH secretion (Kojima et al., 1999), the ghrelin-ghrelin receptor system participates in appetite stimulation, body temperature regulation, and cardioprotection (Nakazato et al., 2001

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5.1 pH-sensitive linkers and infectious microenvironments Acidic environments are typical of numerous pathogenic processes and offer targetable physicochemical signals for facilitating selective payload release