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Andrade-Cetto A, Vazquez RC

[PMID: 16614379] [31] Mastorakos G, Pavlatou M

As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (58) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (61, 62)

This product is termed thermolabile since enzyme activity is reduced at temperatures above 37 C [11]