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Concomitantly, CKD patients exhibit profound downregulation of organic anion transporter OAT1/OAT3 expression within renal and hepatic parenchyma, accompanied by compromised efflux pump BCRP and MRP2/4 functionality, ultimately precipitating catastrophic systemic uremic toxin bioaccumulation (Masereeuw, 2022

Serum pharmacokinetics and organ distribution These promising in vitro results prompted us to investigate the biodistribution and anticancer activity in vivo against a colon cancer mouse model

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