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10.1111/cpr.13779 125 ZhangZ.YuanD.JinX.ChangW.ZhangY.XieW
These pathways rely on cofactors like vitamin B6, folate, and BH4 (tetrahydrobiopterin)
Such vascular responses are particularly relevant in experimental models of ischemia, where enhanced circulation contributes to tissue preservation and recovery.(22) In addition to its effects on vascular growth, it has been associated with regulation of vascular tone through interactions with nitric oxidedependent signaling mechanisms
Further rigorous research is needed to validate these claims
