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The whole process of radical-induced toxicity appears to stem from the generation of oxygen radicals (superoxide anion or singlet oxygen radical) from which other reactive oxygen species (ROS) and reactive nitrogen species (RNS) can be derived

doi: 10.3233/JAD-2011-110209

One pivotal trial followed patients taking 600mg of racemic ALA daily for four years and found no significant safety concerns.7 We explore the differences between racemic ALA and R-ALA later in the guide, but its worth noting here: racemic ALA has the strongest long-term safety data in humans

The best choice depends on goals, health, tolerance, and budget