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In humans, the effective doses seen in vitro (usually 1050 uM) are challenging to achieve without extremely high doses of the compound, which undermine its safety and tolerability [387]
and progesterone during pregnancy for a successful gestation

The modifications are real and chemically meaningful, but the leap from this version is more chemically stable to you need 1/50th the dose involves more assumption than measurement

Low levels of B12 cause a reduction in the formation of red blood cells
