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Therefore, it is reasonable to speculate that some of these members contribute to protection against autoimmune destruction
The antioxidant properties of several natural compounds related to the activation of NRF-2 have been investigated [43], such as curcumin [97], KIOM-4, Resveratrol, Zinc, Berberine, L-arginine, oleanolic acid, vitamin D, among others, in animal cell cultures, with disagreeing results, mainly focused on the decrease of OS or the increase of elements of antioxidant response through NRF-2 [43]

Another study compared germ-free mice with colonized mice to analyze the impact of microbiota on organ damage in hypertension

Stiewe T, Haran TE (2018) How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance
