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5 However, caution is warranted on consuming these large doses, as excess intake can cause toxicity

Contact your GP or prescribing clinician if you experience cold intolerance accompanied by other symptoms that might suggest thyroid dysfunction, such as: Extreme fatigue or weakness that interferes with daily activities Unexplained weight gain or cessation of weight loss despite adherence to treatment Significant hair loss or changes in hair texture Persistent constipation unresponsive to usual measures Dry, flaky skin or changes in skin texture Muscle aches, cramps, or weakness Slowed heart rate Depression or significant mood changes Cognitive difficulties, including memory problems or difficulty concentrating These symptoms could indicate hypothyroidism , which requires investigation through thyroid function tests (TSH, free T4)

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NNMT inhibitor caused weight loss and reduced adipose tissue mass in DIO mice Since in vitro studies showed 5-amino-1MQ to have high cell permeability, enzyme selectivity, and cell culture efficacy, a sub-chronic (11-day) proof-of-concept in vivo study was conducted to test the effect of NNMT inhibition on obesity in HFD fed mice