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Increasing [GSH] i with SFN pretreatment protected cells against peroxide toxicity: upon 500 M tBuOOH, cell survival was 49 12% ( n = 8) in cells treated with SFN, as compared to 18 3% obtained in control cells (Figure 1B)

Thus, SIRTs regulates its transcriptional activity by regulating non-histone acetylation levels, which affects the autophagic process of cells

It downregulates mitochondrial membrane potential, causing pro-apoptotic factors such as Bax, Bid, and Bak to bind to the mitochondrial membrane, disrupt it, release Cytc, and activate Caspase-9, which then activates Caspase-3, inducing cell death (148)

34 , e2201956 (2022)